Telomere Length Assessment in Human Archival Tissues
نویسندگان
چکیده
منابع مشابه
Telomere Length Correlations among Somatic Tissues in Adult Zebra Finches
Telomeres are repetitive non coding DNA sequences located at the end of eukaryotic chromosomes, which maintain the integrity of the genome by hiding the chromosome ends from being recognised as double stranded breaks. Telomeres are emerging as biomarkers for ageing and survival, and are susceptible to reflect different individual life history trajectories. In particular, the telomere length wit...
متن کاملComparison of the relative telomere length measured in leukocytes and eleven different human tissues.
The relative length of telomeres measured in peripheral blood leukocytes is a commonly used system marker for biological aging and can also be used as a biomarker of cardiovascular aging. However, to what extent the telomere length in peripheral leukocytes reflects telomere length in different organ tissues is still unclear. Therefore, we have measured relative telomere length (rTL) in twelve d...
متن کاملHeterogeneity in telomere length of human chromosomes.
Vertebrate chromosomes terminate in variable numbers of T2AG3 nucleotide repeats. In order to study telomere repeats at individual chromosomes, we developed novel, quantitative fluorescence in situ hybridization procedures using labeled (C3TA2)3 peptide nucleic acid and digital imaging microscopy. Telomere fluorescence intensity values from metaphase chromosomes of cultured human hematopoietic ...
متن کاملTelomere length abnormalities and human cancer.
With great interest we read the article by Meeker et al. (1) on abnormalities of telomere length occurring early in the initiation of epithelial carcinogenesis. From in situ assessment of telomere length in formalin-fixed human surgical specimens of epithelial cancer precursor lesions, it was concluded that this methodology may be useful as an early biomarker for monitoring disease prevention s...
متن کاملReproducibility of telomere length assessment: an international collaborative study
BACKGROUND Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and between laboratories. METHODS We instigated an international collaborative study of telomere length assessment: 10 different laboratories, employin...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2002
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)62553-9